Annamaria Morelli Selected Research

BXL628

4/2009	The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.
3/2007	Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol).
2/2007	BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder.
2/2005	Human bladder as a novel target for vitamin D receptor ligands.

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Annamaria Morelli Research Topics

Disease

18	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2021 - 12/2009
17	Inflammation (Inflammations) 01/2021 - 03/2007
17	Hypogonadism (Hypergonadotropic Hypogonadism) 07/2020 - 04/2004
9	Fibrosis (Cirrhosis) 07/2020 - 01/2012
9	Erectile Dysfunction 12/2014 - 03/2006
8	Hypoxia (Hypoxemia) 01/2017 - 05/2006
6	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 03/2013 - 02/2007
6	Lower Urinary Tract Symptoms 03/2013 - 02/2007
5	Insulin Resistance 01/2018 - 01/2012
5	Hypersensitivity (Allergy) 05/2014 - 05/2006
3	Obesity 01/2021 - 08/2010
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 02/2018
3	Hyperglycemia 08/2011 - 01/2009
3	Overactive Urinary Bladder (Overactive Bladder) 01/2010 - 05/2008
2	Hypertension (High Blood Pressure) 04/2022 - 02/2021
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2012
2	Glucose Intolerance 01/2014 - 01/2011
2	Dyslipidemias (Dyslipidemia) 06/2013 - 08/2011
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/2011 - 01/2011
2	Atrophy 05/2007 - 03/2006
1	Multiple Myeloma 11/2021
1	Neuroinflammatory Diseases 01/2021
1	Cognitive Dysfunction 01/2020
1	Necrosis 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 12/2018
1	Non-alcoholic Fatty Liver Disease 01/2018
1	Hypercholesterolemia 01/2018
1	Lung Diseases (Lung Disease) 11/2017
1	Vascular Remodeling 11/2017
1	Idiopathic Pulmonary Fibrosis 01/2017
1	Right Ventricular Hypertrophy 01/2017
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2017
1	Pulmonary Arterial Hypertension 01/2017
1	Pulmonary Hypertension 01/2017
1	Psychological Sexual Dysfunctions (Sexual Arousal Disorder) 12/2016
1	Sarcopenia 06/2016
1	Amenorrhea 06/2016
1	Anemia 06/2016
1	Fatigue 06/2016
1	Metabolic Bone Diseases (Osteopenia) 06/2016

Drug/Important Bio-Agent (IBA)

16	Testosterone (Sustanon)FDA Link 02/2021 - 05/2004
9	AndrogensIBA 10/2020 - 05/2004
7	Messenger RNA (mRNA)IBA 01/2020 - 05/2006
7	Tadalafil (Cialis)FDA Link 03/2016 - 05/2006
7	Phosphodiesterase 5 InhibitorsIBA 09/2013 - 03/2007
6	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2019 - 04/2004
6	obeticholic acidIBA 01/2017 - 01/2011
5	Glucose (Dextrose)FDA LinkGeneric 02/2021 - 01/2011
5	Sildenafil Citrate (Viagra)FDA Link 07/2020 - 05/2004
5	Interleukin-6 (Interleukin 6)IBA 01/2017 - 01/2012
5	Estradiol (Delestrogen)FDA LinkGeneric 03/2013 - 04/2004
5	rho-Associated KinasesIBA 06/2009 - 02/2007
4	Insulin (Novolin)FDA Link 01/2018 - 08/2011
4	Estrogens (Estrogen)FDA Link 12/2016 - 08/2005
4	Y 27632IBA 05/2014 - 05/2007
4	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 03/2013 - 03/2006
4	BXL628IBA 04/2009 - 02/2005
3	Neuroprotective AgentsIBA 02/2021 - 02/2018
3	LipidsIBA 01/2018 - 08/2011
3	Acetylcholine (Acetylcholine Chloride)FDA Link 03/2014 - 03/2006
3	Vardenafil Dihydrochloride (Levitra)FDA Link 09/2013 - 03/2007
3	Interleukin-8 (Interleukin 8)IBA 09/2013 - 01/2012
3	Calcitriol Receptors (Calcitriol Receptor)IBA 04/2009 - 02/2007
3	Proteins (Proteins, Gene)FDA Link 05/2006 - 05/2004
2	CytokinesIBA 08/2020 - 01/2017
2	NF-kappa B (NF-kB)IBA 01/2020 - 04/2009
2	6-ethyl-24-norcholane-3,7,23-triol-23 sulfateIBA 01/2018 - 11/2017
2	SteroidsIBA 11/2017 - 08/2009
2	Hormones (Hormone)IBA 11/2017 - 08/2011
2	Bleomycin (Blenoxane)FDA LinkGeneric 11/2017 - 01/2017
2	MonocrotalineIBA 11/2017 - 01/2017
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2014 - 03/2007
2	Biomarkers (Surrogate Marker)IBA 09/2013 - 06/2013
2	Androgen Receptors (Androgen Receptor)IBA 06/2013 - 07/2012
2	Endothelin-1 (Endothelin 1)IBA 10/2011 - 01/2010
2	Streptozocin (Streptozotocin)FDA Link 01/2011 - 05/2007
2	DesminIBA 01/2010 - 02/2005
2	Triptorelin Pamoate (Trelstar)FDA Link 08/2005 - 04/2004
2	testosterone enanthate (Delatestryl)FDA LinkGeneric 08/2005 - 04/2004
1	HDL LipoproteinsIBA 04/2022
1	LDL CholesterolIBA 04/2022
1	Lenalidomide (CC 5013)FDA Link 11/2021
1	PalmitatesIBA 01/2021
1	daidzeinIBA 01/2021
1	Phytoestrogens (Phytoestrogen)IBA 01/2021
1	Cholinergic Agents (Cholinergics)IBA 01/2020
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2020
1	KisspeptinsIBA 01/2019
1	Dynorphins (Dynorphin)IBA 01/2019
1	QuercetinIBA 02/2018
1	PolyphenolsIBA 02/2018
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2018
1	Bile Acids and Salts (Bile Acids)IBA 11/2017
1	6alpha-ethyl-23(S)-methylcholic acidIBA 11/2017
1	pirfenidoneIBA 01/2017
1	CollagenIBA 01/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2017

Therapy/Procedure

4	Therapeutics 12/2018 - 02/2005
2	Prostatectomy (Retropubic Prostatectomy) 06/2013 - 05/2009
1	Endurance Training 07/2020